A study performed at New York University School of Medicine in Manhattan shows that injectable PLLA (poly-L-lactic acid), a biodegradable synthetic product called Sculptra, is more effective than collagen at correcting nasolabial fold wrinkles. Nasolabial wrinkles are often called the “parentheses,” as they form lines from the sides of the nose down to the sides of the lips and are one of the first signs of aging.

Using the Wrinkle Assessment Scale, PLLA showed a much better correction than collagen and the results lasted longer. Corrections were still visible 25 months after the last treatment.

“The results of this study demonstrate that injectable PLLA is safe and effective for the cosmetic correction of nasolabial fold wrinkles…and that the improvement is gradual and long-lasting, maintained for up to 25 months after last treatment,” stated Dr. Rhoda Narins, one of the researchers. “The efficacy of injectable PLLA will provide subjects and physicians with a new treatment option for the correction of nasolabial fold wrinkles.”

The study was published in the March 2010 issue of the Journal of the American Academy of Dermatology.

To your health and beauty,

Dr. Mitchell Chasin

Medical Director at

Dr. Mitchell Chasin founded Reflections Center for skin & body as a place where physicians specializing in cosmetic medicine could focus on helping empower patients to feel their most beautiful. Dr. Chasin believes strongly that the best cosmetic physicians are those who are dedicated to mastering their craft through continuing education and collaboration with the industry’s top doctors.

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